Article
An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.
Molecular & cellular proteomics : MCP - 1 Mar 2016
Ruggles Kelly V, Tang Zuojian, Wang Xuya, Grover Himanshu, Askenazi Manor, Teubl Jennifer, Cao Song, McLellan Michael D, Clauser Karl R, Tabb David L, Mertins Philipp, Slebos Robbert, Erdmann-Gilmore Petra, Li Shunqiang, Gunawardena Harsha P, Xie Ling, Liu Tao, Zhou Jian-Ying, Sun Shisheng, Hoadley Katherine A, Perou Charles M, Chen Xian, Davies Sherri R, Maher Christopher A, Kinsinger Christopher R, Rodland Karen D, Zhang Hui, Zhang Zhen, Ding Li, Townsend R Reid, Rodriguez Henry, Chan Daniel, Smith Richard D, Liebler Daniel C, Carr Steven A, Payne Samuel, Ellis Matthew J, Fenyő David
Abstract excerpt
Improvements in mass spectrometry (MS)-based peptide sequencing provide a new opportunity to determine whether polymorphisms, mutations, and splice variants identified in cancer cells are translated. Herein, we apply a proteogenomic data integration tool (QUILTS) to illustrate protein variant discovery using whole genome, whole transcriptome, and global proteome datasets generated from a pair of luminal and...
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