Article
Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.
Molecular & cellular proteomics : MCP - 1 Jan 2016
Ntai Ioanna, LeDuc Richard D, Fellers Ryan T, Erdmann-Gilmore Petra, Davies Sherri R, Rumsey Jeanne, Early Bryan P, Thomas Paul M, Li Shunqiang, Compton Philip D, Ellis Matthew J C, Ruggles Kelly V, Fenyö David, Boja Emily S, Rodriguez Henry, Townsend R Reid, Kelleher Neil L
Abstract excerpt
Bottom-up proteomics relies on the use of proteases and is the method of choice for identifying thousands of protein groups in complex samples. Top-down proteomics has been shown to be robust for direct analysis of small proteins and offers a solution to the "peptide-to-protein" inference problem inherent with bottom-up approaches. Here, we describe the first large-scale integration of genomic, bottom-up and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.