Article
Variant peptide detection utilizing mass spectrometry: laying the foundations for proteogenomic identification and validation.
Clinical chemistry and laboratory medicine - 28 Aug 2017
Dimitrakopoulos Lampros, Prassas Ioannis, Berns Els M J J, Foekens John A, Diamandis Eleftherios P, Charames George S
Abstract excerpt
BACKGROUND: Proteogenomics is an emerging field at the intersection of genomics and proteomics. Many variant peptides corresponding to single nucleotide variations (SNVs) are associated with specific diseases. The aim of this study was to demonstrate the feasibility of proteogenomic-based variant peptide detection in disease models and clinical specimens. METHODS: We sought to detect p53 single amino acid variant...
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