Article
Proteogenomics of Malignant Melanoma Cell Lines: The Effect of Stringency of Exome Data Filtering on Variant Peptide Identification in Shotgun Proteomics.
Journal of proteome research - 4 May 2018
Lobas Anna A, Pyatnitskiy Mikhail A, Chernobrovkin Alexey L, Ilina Irina Y, Karpov Dmitry S, Solovyeva Elizaveta M, Kuznetsova Ksenia G, Ivanov Mark V, Lyssuk Elena Y, Kliuchnikova Anna A, Voronko Olga E, Larin Sergey S, Zubarev Roman A, Gorshkov Mikhail V, Moshkovskii Sergei A
Abstract excerpt
The identification of genetically encoded variants at the proteome level is an important problem in cancer proteogenomics. The generation of customized protein databases from DNA or RNA sequencing data is a crucial stage of the identification workflow. Genomic data filtering applied at this stage may significantly modify variant search results, yet its effect is generally left out of the scope of proteogenomic...
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