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Article

Conformational dynamics of stem II of the U2 snRNA.

RNA (New York, N.Y.) - 1 Feb 2016

Rodgers Margaret L, Tretbar U Sandy, Dehaven Alexander, Alwan Amir A, Luo George, Mast Hannah M, Hoskins Aaron A

Abstract excerpt

The spliceosome undergoes dramatic changes in both small nuclear RNA (snRNA) composition and structure during assembly and pre-mRNA splicing. It has been previously proposed that the U2 snRNA adopts two conformations within the stem II region: stem IIa or stem IIc. Dynamic rearrangement of stem IIa into IIc and vice versa is necessary for proper progression of the spliceosome through assembly and catalysis. How...

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Identifiers

PMID: 26631165
DOI: 10.1261/rna.052233.115
PMCID: PMC4712673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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