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Article

Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.

Genome biology - 3 Dec 2015

Etard Christelle, Armant Olivier, Roostalu Urmas, Gourain Victor, Ferg Marco, Strähle Uwe

Abstract excerpt

BACKGROUND: Mutations in myosin chaperones Unc45b and Hsp90aa1.1 as well as in the Unc45b-binding protein Smyd1b impair formation of myofibrils in skeletal muscle and lead to the accumulation of misfolded myosin. The concomitant transcriptional response involves up-regulation of the three genes encoding these proteins, as well as genes involved in muscle development. The transcriptional up-regulation of unc45b,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26631063
DOI: 10.1186/s13059-015-0825-8
PMCID: PMC4668643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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