Article
Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy.
G3 (Bethesda, Md.) - 18 Jan 2021
Tallo Christian A, Duncan Laura H, Yamamoto Akihiko H, Slaydon Joshua D, Arya Gunjan H, Turlapati Lavanya, Mackay Trudy F C, Carbone Mary A
Abstract excerpt
In cats, mutations in myosin binding protein C (encoded by the MYBPC3 gene) have been associated with hypertrophic cardiomyopathy (HCM). However, the molecular mechanisms linking these mutations to HCM remain unknown. Here, we establish Drosophila melanogaster as a model to understand this connection by generating flies harboring MYBPC3 missense mutations (A31P and R820W) associated with feline HCM. The A31P and...
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