Article
Protein quality control gets muscle into shape.
Trends in cell biology - 1 Jun 2008
Kim Johnny, Löwe Thomas, Hoppe Thorsten
Abstract excerpt
The synthesis, assembly and organisation of structural and motor proteins during muscle formation requires temporal and spatial control directed by specialized chaperones. For example, alphaB-crystallin, GimC and TRiC facilitate the assembly of sarcomeric proteins such as desmin and actin. Recent studies have demonstrated that the chaperone family of UCS proteins (UNC-45-CRO1-She4p) is required for the proper...
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