The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.

doi:10.1016/j.ydbio.2006.11.027

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Article

The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.

Developmental biology - 15 Mar 2007

Wohlgemuth Serene L, Crawford Bryan D, Pilgrim David B

Abstract excerpt

The assembly of myosin into higher order structures is dependent upon accessory factors that are often tissue-specific. UNC-45 acts as such a molecular chaperone for myosin in the nematode Caenorhabditis elegans, in both muscle and non-muscle contexts. Although vertebrates contain homologues of UNC-45, their requirement for muscle function has not been assayed. We identified a zebrafish gene, unc45b, similar to a...

Topics

Animals
Base Sequence
Craniofacial Abnormalities
Heart
Mesoderm
Molecular Sequence Data
Muscle Proteins
Muscle, Skeletal
Mutation
Myosins
Oligodeoxyribonucleotides, Antisense
Zebrafish
Zebrafish Proteins

Source

Open in PubMed

Identifiers

PMID: 17189627
DOI: 10.1016/j.ydbio.2006.11.027

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