Article
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.
Developmental biology - 15 Mar 2007
Wohlgemuth Serene L, Crawford Bryan D, Pilgrim David B
Abstract excerpt
The assembly of myosin into higher order structures is dependent upon accessory factors that are often tissue-specific. UNC-45 acts as such a molecular chaperone for myosin in the nematode Caenorhabditis elegans, in both muscle and non-muscle contexts. Although vertebrates contain homologues of UNC-45, their requirement for muscle function has not been assayed. We identified a zebrafish gene, unc45b, similar to a...
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