Article
The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis.
Developmental biology - 1 Aug 2007
Etard Christelle, Behra Martine, Fischer Nadine, Hutcheson David, Geisler Robert, Strähle Uwe
Abstract excerpt
Contraction of muscles is mediated by highly organized arrays of myosin motor proteins. We report here the characterization of a mutation of a UCS gene named steif/unc-45b that is required for the formation of ordered myofibrils in both the skeletal and cardiac muscles of zebrafish. We show that Steif/Unc-45b interacts with the chaperone Hsp90a in vitro. The two genes are co-expressed in the skeletal musculature...
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