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Article

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.

Cell stem cell - 4 Feb 2016

Qian Pengxu, He Xi C, Paulson Ariel, Li Zhenrui, Tao Fang, Perry John M, Guo Fengli, Zhao Meng, Zhi Lei, Venkatraman Aparna, Haug Jeffrey S, Parmely Tari, Li Hua, Dobrowsky Rick T, Ding Wen-Xing, Kono Tomohiro, Ferguson-Smith Anne C, Li Linheng

Abstract excerpt

The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the mammalian genome. This locus has characterized functions in some types of stem cell, but its role in hematopoietic stem cells (HSCs) is unknown. Here, we show that the Dlk1-Gtl2 locus plays a critical role in preserving long-term repopulating HSCs...

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Identifiers

PMID: 26627594
DOI: 10.1016/j.stem.2015.11.001
PMCID: PMC5545934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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