Article
Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.
Development (Cambridge, England) - 1 Aug 2010
Zhou Yunli, Cheunsuchon Pornsuk, Nakayama Yuki, Lawlor Michael W, Zhong Ying, Rice Kimberley A, Zhang Li, Zhang Xun, Gordon Francesca E, Lidov Hart G W, Bronson Roderick T, Klibanski Anne
Abstract excerpt
The Dlk1-Gtl2 imprinting locus is located on mouse distal chromosome 12 and consists of multiple maternally expressed non-coding RNAs and several paternally expressed protein-coding genes. The imprinting of this locus plays a crucial role in embryonic development and postnatal growth. At least one cis-element, the intergenic differentially methylated region (IG-DMR) is required for expression of maternally...
Topics
- Alleles
- Animals
- Base Sequence
- Calcium-Binding Proteins
- DNA Methylation
- Female
- Gene Deletion
- Gene Expression Regulation, Developmental
- Gene Silencing
- Intercellular Signaling Peptides and Proteins