Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma.

The Journal of reproduction and development - 1 Jan 2015

Takahashi Nozomi, Yamaguchi Eito, Kawabata Yukiko, Kono Tomohiro

Abstract excerpt

The distal region of mouse chromosome 12 harbors the Dlk1-Dio3 domain, is essential for normal development and encodes maternally expressed noncoding RNAs (ncRNAs), including Gtl2 as well as paternally expressed proteins.Gtl2 works as a tumor suppressor in several types of human cancer cell lines; however, whether this reflects its function in vivo is unknown. Deleting Gtl2 from the maternal allele (Gtl2((-/+)))...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Imprinting

Share to Iodide Peroxidase

Share to Mice, SCID

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Teratoma

Source

Open in PubMed Open full text

Identifiers

PMID: 25355544
DOI: 10.1262/jrd.2014-089
PMCID: PMC4354225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma.PMID 25355544Read ↗

Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.Semantic proximity Read ↗

Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.Semantic proximity Read ↗

Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testesSemantic proximity Read ↗

Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineageSemantic proximity Read ↗

Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain.Semantic proximity Read ↗

Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of boneSemantic proximity Read ↗

The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.Semantic proximity Read ↗

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.Semantic proximity Read ↗

PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.Semantic proximity Read ↗

A short PIWIL2 isoform PL2L60A induces functional and transcriptional changes indicative of a procancerous phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.