Article

Ancient genomic linkage couples metabolism with erythroid development

2023-09-25

Abstract excerpt

Generation of mature cells from progenitors requires tight coupling of differentiation and metabolism. During erythropoiesis, erythroblasts are required to massively upregulate globin synthesis then clear extraneous material and enucleate to produce erythrocytes 1–3 . Nprl3 has remained in synteny with the α-globin genes for >500 million years 4 , and harbours the majority of the α-globin enhancers 5 . Nprl3 i...

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Literature Corpus work: d54c20c6-b293-5d34-86f3-cffcc8f0f914
DOI: 10.1101/2023.09.25.558944

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