Article

Lin28 Enhances Glucose Metabolism in Human Placental Mesenchymal Stem Cells during Hypoxia via the PI3K-Akt Pathway

2021-09-21

Abstract excerpt

Mesenchymal stem cells (MSCs) are widely used to treat and prevent liver ischemia–reperfusion injury (LIRI), which commonly occurs after liver surgery. Lin28 is an RNA-binding protein crucial for early embryonic development, stem cell differentiation/reprogramming, tumorigenesis, and metabolism. However, whether Lin28 can enhance metabolism in human placental MSCs (PMSCs) during hypoxia to improve the protective e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 500f3a25-16e9-5caa-94b2-354f9a5ee181
DOI: 10.21203/rs.3.rs-892582/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lin28 Enhances Glucose Metabolism in Human Placental Mesenchymal Stem Cells during Hypoxia via the PI3K-Akt PathwayDOI 10.21203/rs.3.rs-892582/v1Read

Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxiaSemantic proximity Read

Inhibition of the PI3K-Akt Pathway Suppresses sFlt1 Expression in Human Placental Hypoxia Models In VitroSemantic proximity Read

Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and PluripotencySemantic proximity Read

The Metabolism Reprogramming of microRNA Let-7-Mediated Glycolysis Contributes to Autophagy and Tumor ProgressionSemantic proximity Read

Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1Semantic proximity Read

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.Semantic proximity Read

Enhanced PRL-1 expression in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat modelSemantic proximity Read

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122Semantic proximity Read

Insulin-induced Gene 2 Protects against Hepatic Ischemia-reperfusion Injury via Metabolic RemodelingSemantic proximity Read

KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagySemantic proximity Read

Glucose and lipid metabolisms in human endometrial stromal cells during decidualizationSemantic proximity Read

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiationSemantic proximity Read