Article
Defining the blueprint of the cancer genome.
Carcinogenesis - 1 Jun 2008
Velculescu Victor E
Abstract excerpt
It is widely accepted that cancer is a disease caused by accumulation of mutations in specific genes. These tumor-specific mutations provide clues to the cellular processes underlying tumorigenesis and have proven useful for diagnostic and therapeutic purposes. To date, however, only a small fraction of genes has been analyzed and the number and type of alterations responsible for the development of common tumor...
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