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Article

The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer.

Gene - 15 Feb 2016

Shin Kyung Min, Jung Deuk Kju, Hong Mi Jeong, Kang Hyo Jung, Lee Won Kee, Yoo Seung Soo, Lee Shin Yup, Cha Seung Ick, Lee Jaehee, Kim Chang Ho, Seok Yangki, Cho Sukki, Son Ji Woong, Lee Eung Bae, Jheon Sanghoon, Kim Young Tae, Park Jae Yong

Abstract excerpt

BACKGROUND: Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC). METHOD: A total of 761...

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PMID: 26625972
DOI: 10.1016/j.gene.2015.11.036

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