Article
MicroRNA-related genetic variants associated with clinical outcomes in early-stage non-small cell lung cancer patients.
Cancer research - 15 Mar 2013
Pu Xia, Roth Jack A, Hildebrandt Michelle A T, Ye Yuanqing, Wei Hua, Minna John D, Lippman Scott M, Wu Xifeng
Abstract excerpt
Given the density of single-nucleotide polymorphisms (SNP) in the human genome and the sensitivity of single-nucleotide changes in microRNA (miRNA) functionality and processing, we asked whether polymorphisms within miRNA processing pathways and binding sites may influence non-small cell lung cancer (NSCLC) patients' prognosis. We genotyped 240 miRNA-related SNPs in 535 patients with stage I and II NSCLCs to...
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