Article
Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival.
American journal of respiratory and critical care medicine - 1 Mar 2011
Hu Zhibin, Shu Yongqian, Chen Yijiang, Chen Jiaping, Dong Jing, Liu Yao, Pan Shiyang, Xu Lin, Xu Jing, Wang Yi, Dai Juncheng, Ma Hongxia, Jin Guangfu, Shen Hongbing
Abstract excerpt
RATIONALE: Previously, we reported that common variants in precursor microRNA (pre-miRNA) sequences played a role in the prediction of non-small cell lung cancer (NSCLC) survival. OBJECTIVES: To assess whether variants in the pre-miRNA flanking region can influence the clinical behavior of NSCLC. METHODS: We conducted a two-stage study to examine the impact of a panel of 85 single-nucleotide polymorphisms on the...
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