Article
The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer.
The Journal of thoracic and cardiovascular surgery - 1 Oct 2012
Yoon Kyong-Ah, Yoon Hyekyoung, Park Sohee, Jang Hee-Jin, Zo Jae Ill, Lee Hyun-Sung, Lee Jin Soo
Abstract excerpt
OBJECTIVES: MicroRNAs (miRNAs) are widely known for their function as regulators of gene expression via translational repression. Polymorphisms in miRNAs have been shown to affect the regulatory capacity of miRNAs by influencing miRNA processing and/or miRNA-mRNA interactions. The purpose of this study was to investigate the association between 7 single nucleotide polymorphisms (SNPs) commonly found in precursor...
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