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Article

A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.

Cancer research - 15 Oct 2008

Chin Lena J, Ratner Elena, Leng Shuguang, Zhai Rihong, Nallur Sunitha, Babar Imran, Muller Roman-Ulrich, Straka Eva, Su Li, Burki Elizabeth A, Crowell Richard E, Patel Rajeshvari, Kulkarni Trupti, Homer Robert, Zelterman Daniel, Kidd Kenneth K, Zhu Yong, Christiani David C, Belinsky Steven A, Slack Frank J, Weidhaas Joanne B

Abstract excerpt

Lung cancer is the leading cause of cancer deaths worldwide, yet few genetic markers of lung cancer risk useful for screening exist. The let-7 family-of-microRNAs (miRNA) are global genetic regulators important in controlling lung cancer oncogene expression by binding to the 3' untranslated regio...

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Identifiers

PMID: 18922928
DOI: 10.1158/0008-5472.CAN-08-2129
PMCID: PMC2672193

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18922928-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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