Article
A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese.
Genetics and molecular research : GMR - 4 May 2015
Shen L Q, Xie Y Z, Qian X F, Zhuang Z X, Jiao Y, Qi X F
Abstract excerpt
Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we examined whether a...
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