Article
A potentially functional polymorphism in the promoter region of let-7 family is associated with survival of hepatocellular carcinoma.
Cancer epidemiology - 1 Dec 2013
Xie Kaipeng, Liu Jibin, Zhu Liguo, Liu Yao, Pan Yun, Wen Juan, Ma Hongxia, Zhai Xiangjun, Hu Zhibin
Abstract excerpt
BACKGROUND: The let-7 family plays a vital role in the normal cellular activity of liver cells and the carcinogenesis of hepatocellular carcinoma (HCC). In the previous study, we have detected the association between single nucleotide polymorphisms (SNPs) in the promoter region of let-7 and susceptibility to HCC. However, it is still unknown whether these polymorphisms are associated with HCC prognosis. METHODS:...
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