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Article

Conductance of connexin hemichannels segregates with the first transmembrane segment.

Biophysical journal - 1 Jan 2006

Hu Xinge, Ma Meiyun, Dahl Gerhard

Abstract excerpt

Gap junction channels are intercellular channels that mediate the gated transfer of molecules between adjacent cells. To identify the domain determining channel conductance, the first transmembrane segment (M1) was reciprocally exchanged between Cx46 and Cx32E(1)43. The resulting chimeras exhibited conductances similar to that of the respective M1 donor. Furthermore, a chimera with the carboxy-terminal half of M1...

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Identifiers

PMID: 16214855
DOI: 10.1529/biophysj.105.066373
PMCID: PMC1367013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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