Article
Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.
Biochimica et biophysica acta - 1 Aug 2012
Beyer Eric C, Lipkind Gregory M, Kyle John W, Berthoud Viviana M
Abstract excerpt
The amino terminal domain (NT) of the connexins consists of their first 22-23 amino acids. Site-directed mutagenesis studies have demonstrated that NT amino acids are determinants of gap junction channel properties including unitary conductance, permeability/selectivity, and gating in response to transjunctional voltage. The importance of this region has also been emphasized by the identification of multiple...
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