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Article

Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci?

PloS one - 1 Jan 2015

Barber Robert C, Phillips Nicole R, Tilson Jeffrey L, Huebinger Ryan M, Shewale Shantanu J, Koenig Jessica L, Mitchel Jeffrey S, O'Bryant Sid E, Waring Stephen C, Diaz-Arrastia Ramon, Chasse Scott, Wilhelmsen Kirk C

Abstract excerpt

Although 24 Alzheimer's disease (AD) risk loci have been reliably identified, a large portion of the predicted heritability for AD remains unexplained. It is expected that additional loci of small effect will be identified with an increased sample size. However, the cost of a significant increase in Case-Control sample size is prohibitive. The current study tests whether exploring the genetic basis of...

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PMID: 26625115
DOI: 10.1371/journal.pone.0142360
PMCID: PMC4666664

Genes

CLU
PICALM
TREM1
VCAM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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