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Article

Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.

Scientific reports - 12 Apr 2022

Heath Laura, Earls John C, Magis Andrew T, Kornilov Sergey A, Lovejoy Jennifer C, Funk Cory C, Rappaport Noa, Logsdon Benjamin A, Mangravite Lara M, Kunkle Brian W, Martin Eden R, Naj Adam C, Ertekin-Taner Nilüfer, Golde Todd E, Hood Leroy, Price Nathan D

Abstract excerpt

Genetics play an important role in late-onset Alzheimer's Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. However, the precise mechanistic effects of most of these variants have yet to be determined. Deeply phenotyped cohort data can reveal physiological changes associated with genetic risk for AD across an age spectrum that may provide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35413975
DOI: 10.1038/s41598-022-09825-2
PMCID: PMC9005657

Genes

ABCA7
NYAP1
PICALM
PILRA
APOE
INPP5D
PILRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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