Article
High CR1 level and related polymorphic variants are associated with cerebral malaria in eastern-India.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2011
Rout Ronnaly, Dhangadamajhi Gunanidhi, Mohapatra Biranchi N, Kar Shantanu K, Ranjit Manoranjan
Abstract excerpt
The complement receptor 1 (CR1/CD35) protein acts as the major rosetting receptor in Plasmodium falciparum infection and several genetic variants of CR1 gene have been shown to be associated with quantitative expression of erythrocyte CR1 (E-CR1) level. However, CR1 level and gene polymorphisms exhibit differences in clinical manifestation of malaria in regions of varying disease endemicity. The result of the...
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