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Article

DNA methylation signatures in development and aging of the human prefrontal cortex.

American journal of human genetics - 10 Feb 2012

Numata Shusuke, Ye Tianzhang, Hyde Thomas M, Guitart-Navarro Xavier, Tao Ran, Wininger Michael, Colantuoni Carlo, Weinberger Daniel R, Kleinman Joel E, Lipska Barbara K

Abstract excerpt

The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions to mature. To investigate the role of epigenetics in the development of PFC, we examined DNA methylation in ∼14,500 genes at ∼27,000 CpG loci focused on 5' promoter regions in 108 subjects range in age from fetal to elderly. DNA methylation in the PFC shows unique temporal patterns across life. The fastest changes occur...

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Identifiers

PMID: 22305529
DOI: 10.1016/j.ajhg.2011.12.020
PMCID: PMC3276664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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