Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease.

doi:10.1158/1541-7786.MCR-18-0056

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Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease.

Molecular cancer research : MCR - 1 Dec 2018

Nisa Lluís, Barras David, Medová Michaela, Aebersold Daniel M, Medo Matúš, Poliaková Michaela, Koch Jonas, Bojaxhiu Beat, Eliçin Olgun, Dettmer Matthias S, Angelino Paolo, Giger Roland, Borner Urs, Caversaccio Marco D, Carey Thomas E, Ho Liza, McKee Thomas A, Delorenzi Mauro, Zimmer Yitzhak

Abstract excerpt

Metastases and tumor recurrence have a major prognostic impact in head and neck squamous cell carcinoma (HNSCC); however, cellular models that comprehensively characterize metastatic and recurrent HNSCC are lacking. To this end, we obtained genomic, transcriptomic, and copy number profiles of the UM-SCC cell line panel, encompassing patient-matched metastatic and recurrent cells. UM-SCC cells recapitulate the...

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PMID: 30108165
DOI: 10.1158/1541-7786.MCR-18-0056

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