Article
Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma.
Human mutation - 1 Oct 2020
Gorlov Ivan P, Amos Christopher I, Tsavachidis Spiridon, Begg Colin, Hernando Eva, Cheng Chao, Shen Ronglai, Orlow Irene, Luo Li, Ernstoff Marc S, Parker Joel, Thomas Nancy E, Gorlova Olga Y, Berwick Marianne
Abstract excerpt
We hypothesized that human genes differ by their sensitivity to ultraviolet (UV) exposure. We used somatic mutations detected by genome-wide screens in melanoma and reported in the Catalog Of Somatic Mutations In Cancer. As a measure of UV sensitivity, we used the number of silent mutations generated by C>T transitions in pyrimidine dimers of a given transcript divided by the number of potential sites for this...
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