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Article

Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant.

Cold Spring Harbor molecular case studies - 1 Feb 2020

Majounie Elisa, Wee Kathleen, Williamson Laura M, Jones Martin R, Pleasance Erin, Lim Howard J, Ho Cheryl, Renouf Daniel J, Yip Stephen, Jones Steven J M, Marra Marco A, Laskin Janessa

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and represents a heterogeneous group of tumors, the majority of which are treated with a combination of surgery, radiation, and chemotherapy. Fluoropyrimidine (5-FU) and its oral prodrug, capecitabine, are commonly prescribed treatments for several solid tumor types including HNSCC. 5-FU-associated toxicity is observed in...

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Share to Amino Acid Substitution
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biopsy

Share to Dihydrouracil Dehydrogenase (NADP)

Share to Drug Resistance, Neoplasm

Share to Fluorouracil

Share to Sequence Analysis, DNA

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 31871216
DOI: 10.1101/mcs.a004713
PMCID: PMC6996515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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