Article

Global and local redistribution of somatic mutations enable the prediction of functional XPD mutations in bladder cancer

2022-01-21

Abstract excerpt

Xeroderma pigmentosum group D (XPD) is a DNA helicase with critical functions in transcription initiation and nucleotide excision repair. Missense mutations in XPD are putative drivers in around 10% of bladder cancers (BLCA), but the associated mutational process remains poorly understood. Here, we examine the somatic mutational landscape of XPD wild-type (n=343) and mutant (n=39) BLCA whole genomes. The genome-wi...

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Literature Corpus work: 586b702b-8056-5162-a0d5-c73d656ca39e
DOI: 10.1101/2022.01.21.477237

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