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Article

Twenty Years of Presenilins--Important Proteins in Health and Disease.

Molecular medicine (Cambridge, Mass.) - 27 Oct 2015

Walter Jochen

Abstract excerpt

Alzheimer's disease (AD) is characterized by progressive decline in cognitive functions associated with depositions of aggregated proteins in the form of extracellular plaques and neurofibrillary tangles in the brain. Extracellular plaques contain characteristic fibrils of amyloid β peptides (Aβ); tangles consist of paired helical filaments of the microtubuli-associated protein tau. Although AD manifests...

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Identifiers

PMID: 26605647
DOI: 10.2119/molmed.2015.00163
PMCID: PMC4661050

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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