Article
Evolutionary history of Alzheimer Disease causing protein family Presenilins with pathological implications
2018-08-20
Abstract excerpt
Presenilin proteins are type II transmembrane proteins. They make the catalytic component of Gamma secretase, a multiportion transmembrane protease. Amyloid protein, Notch and beta catenin are among more than 90 substrates of Presenilins. Mutations in Presenilins lead to defects in proteolytic cleavage of its substrate resulting in some of the most devastating pathological conditions including Alzheimer disease (A...
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Identifiers and source
- Literature Corpus work
- 796a705b-542a-5ed4-9364-321a9f44e5d8
- DOI
- 10.1101/394270