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Article

Presenilin function in APP processing.

Annals of the New York Academy of Sciences - 1 Jan 2000

Annaert W, Cupers P, Saftig P, De Strooper B

Abstract excerpt

Familial Alzheimer's disease (FAD) is now linked to at least three genes encoding the amyloid precursor protein (APP) on chromosome 21, and presenilin 1 and 2 on chromosome 14 and 1, respectively. FAD cases in whom presenilin mutations occur are more frequent than those with APP mutations. However, altogether they only account for approximately 0.1% of all the people suffering from Alzheimer's disease (AD), and...

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Source

Identifiers

PMID: 11193144
DOI: 10.1111/j.1749-6632.2000.tb06917.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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