Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum.

Article

Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum.

Molecular psychiatry - 1 Dec 1996

Sandbrink R, Beyreuther K

Abstract excerpt

Missense mutations of the presenilins (PS1 and PS2) first identified about one year ago are responsible for the majority of autosomal dominant familial Alzheimer's disease cases. Recent studies suggesting that these mutations exert their disastrous effect by elevating the levels of the longer for...

Topics

Alzheimer Disease
Humans
Membrane Proteins
Mutation
Presenilin-1
Presenilin-2

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