Article
Presenilin structure, function and role in Alzheimer disease.
Biochimica et biophysica acta - 26 Jul 2000
Fraser P E, Yang D S, Yu G, Lévesque L, Nishimura M, Arawaka S, Serpell L C, Rogaeva E, St George-Hyslop P
Abstract excerpt
Numerous missense mutations in the presenilins are associated with the autosomal dominant form of familial Alzheimer disease. Presenilin genes encode polytopic transmembrane proteins, which are processed by proteolytic cleavage and form high-molecular-weight complexes under physiological conditions. The presenilins have been suggested to be functionally involved in developmental morphogenesis, unfolded protein...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Membrane
- Cytoskeletal Proteins
- Hippocampus
- Humans
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data