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Article

Presenilin structure, function and role in Alzheimer disease.

Biochimica et biophysica acta - 26 Jul 2000

Fraser P E, Yang D S, Yu G, Lévesque L, Nishimura M, Arawaka S, Serpell L C, Rogaeva E, St George-Hyslop P

Abstract excerpt

Numerous missense mutations in the presenilins are associated with the autosomal dominant form of familial Alzheimer disease. Presenilin genes encode polytopic transmembrane proteins, which are processed by proteolytic cleavage and form high-molecular-weight complexes under physiological conditions. The presenilins have been suggested to be functionally involved in developmental morphogenesis, unfolded protein...

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PMID: 10899427
DOI: 10.1016/s0925-4439(00)00028-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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