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MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes

24 Nov 2015

Abstract excerpt

Little is known about the mechanisms leading to neurodegeneration in multiple sclerosis (MS) and the role of peripheral blood cells in this neurodegenerative component. We aimed to correlate brain radiological phenotypes defined by high and low neurodegeneration with gene expression profiling of peripheral blood mononuclear cells (PBMC) from MS patients. Magnetic resonance imaging (MRI) scans from 64 patients...

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PMID: 26604134
DOI: 10.1093/hmg/ddv473

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