Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.

doi:10.1158/1078-0432.CCR-15-2209

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2016

Romick-Rosendale Lindsey E, Hoskins Elizabeth E, Privette Vinnedge Lisa M, Foglesong Grant D, Brusadelli Marion G, Potter S Steven, Komurov Kakajan, Brugmann Samantha A, Lambert Paul F, Kimple Randall J, Virts Elizabeth L, Hanenberg Helmut, Gillison Maura L, Wells Susanne I

Abstract excerpt

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) remains a devastating disease, and Fanconi anemia (FA) gene mutations and transcriptional repression are common. Invasive tumor behavior is associated with poor outcome, but relevant pathways triggering invasion are poorly understood. There is a significant need to improve our understanding of genetic pathways and molecular mechanisms driving advanced tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Activated Protein Kinase

Share to Fanconi Anemia Complementation Group Proteins

Share to Gene Knockdown Techniques

Share to Gene Ontology

Share to Head and Neck Neoplasms

Share to rac1 GTP-Binding Protein

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 26603260
DOI: 10.1158/1078-0432.CCR-15-2209
PMCID: PMC4834270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.PMID 26603260Read ↗

Generating new FANCA-deficient HNSCC cell lines by genomic editing recapitulate the cellular phenotypes of Fanconi anemiaSemantic proximity Read ↗

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulate the Cellular Phenotypes of Fanconi AnemiaSemantic proximity Read ↗

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resourceSemantic proximity Read ↗

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia.Semantic proximity Read ↗

Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resourceSemantic proximity Read ↗

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell CarcinomasSemantic proximity Read ↗

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancerSemantic proximity Read ↗

Treatment of Fanconi Anemia–Associated Head and Neck Cancer: Opportunities to Improve OutcomesSemantic proximity Read ↗

Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.Semantic proximity Read ↗

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.Semantic proximity Read ↗

The Fanconi Anemia Pathway Limits Human Papillomavirus ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.