Article

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

2021-08-16

Abstract excerpt

Fanconi anemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink (ICL) repair resulting in chromosome breakage 1–3 . The FA repair pathway comprises at least 22 FANC proteins including BRCA1 and BRCA2 4–6 , and protects against carcinogenic endogenous and exogenous aldehydes 7–10 . Individuals with FA are hundreds to thousands-fold more likely to develop head a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2531d373-d9ec-5e5d-b819-67878a6ae36e
DOI: 10.1101/2021.08.14.456365

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell CarcinomasDOI 10.1101/2021.08.14.456365Read

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancerSemantic proximity Read

The Fanconi Anemia Pathway Limits Human Papillomavirus ReplicationSemantic proximity Read

Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.Semantic proximity Read

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resourceSemantic proximity Read

Head and Neck Cancer Susceptibility and Metabolism in Fanconi AnemiaSemantic proximity Read

Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resourceSemantic proximity Read

Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines.Semantic proximity Read

The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.Semantic proximity Read

Comprehensive genomic characterization of head and neck squamous cell carcinomas.Semantic proximity Read

Germline Pathogenic Variants in Squamous Cell Carcinoma of the Head and Neck.Semantic proximity Read

Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know.Semantic proximity Read

Oral squamous cell carcinoma risk and magnitude of association in inherited cancer predisposition syndromes: evidence from a large real-world cohort.Semantic proximity Read