Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.

doi:10.1016/j.canlet.2016.11.014

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Article

Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.

Cancer letters - 1 Feb 2017

Hess Julia, Unger Kristian, Orth Michael, Schötz Ulrike, Schüttrumpf Lars, Zangen Verena, Gimenez-Aznar Igor, Michna Agata, Schneider Ludmila, Stamp Ramona, Selmansberger Martin, Braselmann Herbert, Hieber Ludwig, Drexler Guido A, Kuger Sebastian, Klein Diana, Jendrossek Verena, Friedl Anna A, Belka Claus, Zitzelsberger Horst, Lauber Kirsten

Abstract excerpt

Radio (chemo) therapy is a crucial treatment modality for head and neck squamous cell carcinoma (HNSCC), but relapse is frequent, and the underlying mechanisms remain largely elusive. Therefore, novel biomarkers are urgently needed. Previously, we identified gains on 16q23-24 to be associated with amplification of the Fanconi anemia A (FancA) gene and to correlate with reduced progression-free survival after...

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PMID: 27867017
DOI: 10.1016/j.canlet.2016.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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