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The Fanconi Anemia Pathway Limits Human Papillomavirus Replication

24 May 2012

Abstract excerpt

High-risk human papillomaviruses (HPVs) deregulate epidermal differentiation and cause anogenital and head and neck squamous cell carcinomas (SCCs). The E7 gene is considered the predominant viral oncogene and drives proliferation and genome instability. While the implementation of routine screens has greatly reduced the incidence of cervical cancers which are almost exclusively HPV positive, the proportion of...

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PMID: 22623785
DOI: 10.1128/jvi.00408-12

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