Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia.

Genes - 9 Apr 2021

Errazquin Ricardo, Sieiro Esther, Moreno Pilar, Ramirez María José, Lorz Corina, Peral Jorge, Ortiz Jessica, Casado José Antonio, Roman-Rodriguez Francisco J, Hanenberg Helmut, Río Paula, Surralles Jordi, Segrelles Carmen, Garcia-Escudero Ramon

Abstract excerpt

Fanconi anemia (FA) patients have an exacerbated risk of head and neck squamous cell carcinoma (HNSCC). Treatment is challenging as FA patients display enhanced toxicity to standard treatments, including radio/chemotherapy. Therefore, better therapies as well as new disease models are urgently needed. We have used CRISPR/Cas9 editing tools in order to interrupt the human FANCA gene by the generation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia

Share to Fanconi Anemia Complementation Group A Protein

Share to Gene Editing

Share to Head and Neck Neoplasms

Share to Squamous Cell Carcinoma of Head and Neck

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 33918752
DOI: 10.3390/genes12040548
PMCID: PMC8069753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia.PMID 33918752Read ↗

Generating new FANCA-deficient HNSCC cell lines by genomic editing recapitulate the cellular phenotypes of Fanconi anemiaSemantic proximity Read ↗

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulate the Cellular Phenotypes of Fanconi AnemiaSemantic proximity Read ↗

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resourceSemantic proximity Read ↗

Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resourceSemantic proximity Read ↗

Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.Semantic proximity Read ↗

Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines.Semantic proximity Read ↗

Diagnosis and Treatment for Squamous Cell Carcinoma of the Oral Tongue in a Patient with Fanconi AnemiaSemantic proximity Read ↗

Generation and Molecular Characterization of Head and Neck Squamous Cell Lines of Fanconi Anemia PatientsSemantic proximity Read ↗

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Semantic proximity Read ↗

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.Semantic proximity Read ↗

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell CarcinomasSemantic proximity Read ↗

FANCD2 Confers a Malignant Phenotype in Esophageal Squamous Cell Carcinoma by Regulating Cell Cycle ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.