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Treatment of Fanconi Anemia–Associated Head and Neck Cancer: Opportunities to Improve Outcomes

27 May 2021

Abstract excerpt

Fanconi anemia, the most frequent genetic cause of bone marrow failure, is characterized by an extreme predilection toward multiple malignancies, including a greater than 500-fold incidence of head and neck squamous cell carcinoma (HNSCC) relative to the general population. Fanconi anemia-associated HNSCC and esophageal SCC (FA-HNSCC) often present at advanced stages with poor survival. Surgical resection remains...

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PMID: 34045293
DOI: 10.1158/1078-0432.ccr-21-1259

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