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Article

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.

Cancer research - 1 Sept 2015

Stoepker Chantal, Ameziane Najim, van der Lelij Petra, Kooi Irsan E, Oostra Anneke B, Rooimans Martin A, van Mil Saskia E, Brink Arjen, Dietrich Ralf, Balk Jesper A, Ylstra Bauke, Joenje Hans, Feller Stephan M, Brakenhoff Ruud H

Abstract excerpt

Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for correct chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of many types of cancers. We investigated how frequent this occurs in head and neck squamous cell carcinoma (HNSCC) and whether specific mechanisms or genes could be linked to these phenotypes. The genomic instability...

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Share to Carcinoma, Squamous Cell
Share to Chromatids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

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Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 26122845
DOI: 10.1158/0008-5472.CAN-15-0528

Genes

FANCF
FANCM
STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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