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Article

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions.

Scientific reports - 25 Nov 2015

Etna Marilena P, Giacomini Elena, Pardini Manuela, Severa Martina, Bottai Daria, Cruciani Melania, Rizzo Fabiana, Calogero Raffaele, Brosch Roland, Coccia Eliana M

Abstract excerpt

Modern strategies to develop vaccines against Mycobacterium tuberculosis (Mtb) aim to improve the current Bacillus Calmette-Guerin (BCG) vaccine or to attenuate the virulence of Mtb vaccine candidates. In the present study, the impact of wild type or mutated region of difference 1 (RD1) variants on the immunogenicity of Mtb and BCG recombinants was investigated in human primary dendritic cells (DC). A comparative...

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PMID: 26602835
DOI: 10.1038/srep17078
PMCID: PMC4658526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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