Article
IFNγ/TNFα specific-cells and effector memory phenotype associate with active tuberculosis.
The Journal of infection - 1 Jun 2013
Petruccioli Elisa, Petrone Linda, Vanini Valentina, Sampaolesi Alessandro, Gualano Gina, Girardi Enrico, Palmieri Fabrizio, Goletti Delia
Abstract excerpt
OBJECTIVES: Controversial results were reported on the role of polyfunctional T-cells in tuberculosis (TB). Our aim was to simultaneously characterize the Mycobacterium tuberculosis (Mtb)-specific immune response as cytokine production and memory phenotype by flow cytometry after in vitro stimulation with region of difference 1 ("RD1") recombinant proteins (ESAT-6 and CFP-10) in patients at different TB stage in...
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