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Article

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.

Mucosal immunology - 1 Jul 2016

Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Esplugues J V, Barrachina M D

Abstract excerpt

The complete repair of the mucosa constitutes a key goal in inflammatory bowel disease (IBD) treatment. The Wnt signaling pathway mediates mucosal repair and M2 macrophages that coordinate efficient healing have been related to Wnt ligand expression. Signal transducer and activator of transcription 6 (STAT6) mediates M2 polarization in vitro and we hypothesize that a STAT6-dependent macrophage phenotype mediates...

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Share to Colitis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

Share to Macrophages, Peritoneal

Share to Mice, Inbred BALB C

Share to STAT6 Transcription Factor

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Source

Identifiers

PMID: 26601901
DOI: 10.1038/mi.2015.123

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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