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Myeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis

1 Jan 2024

Abstract excerpt

Wnt/-catenin signaling plays a pivotal role in the pathogenesis of chronic kidney diseases (CKD), which is associated with macrophage activation and polarization. However, the relative contribution of macrophage-derived Wnts in the evolution of CKD is poorly understood. Here we demonstrate a critical role of Wnts secreted by macrophages in regulating renal inflammation and fibrosis after various injuries. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38617540
DOI: 10.7150/ijbs.94166

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